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INDONESIA
Journal of Pharmaceutical and Health Research
Published by Forum Kerjasama Pendidikan TInggi
ISSN : -     EISSN : 27210715     DOI : https://doi.org/10.47065/jharma.v3i1.1322
Core Subject : Health,
Health Professions Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Health Research memiliki bidang kajian, yaitu: 1. Bidang Gizi Klinis 2. Bidang Gizi Masyarakat 3. Pangan dan Gizi 4. Inovasi Pangan 5. Hematologi 6. Parasitologi 7. Biokimia 8. Laboratorium Kesehatan 9. Teknologi Laboratorium 10. Farmakologi 11. Farmasi 12. Keperawatan Jiwa 13. Keperawatan Anak 14. Keperawatan Maternitas 15. Keperawatan Medikal Bedah 16. Keperawatan Keluarga 17. Keperawatan Komunitas 18. Kesehatan Masyarakat 19. Teknologi Kesehatan
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 31 Documents
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Search results for , issue "Vol 4 No 1 (2023): February 2023" : 31 Documents clear
Excessive Use of Nipah Leaf Membrane Cigarettes Increases the Severity of Spontaneous Pneumothorax: A Case study from Jambi, Indonesia Dwinka Syafira Eljatin; Muhammad Ridho Akbar Eljatin; I Made Dwi Mertha Adnyana; Muhammad Bayu Zohari Hutagalung; Muhamad Frendy Setyawan
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2820

Abstract

Nipah (Nypa fruticans) is a type of palm that is widely used by the community. The local people of Jambi use Nipah leaves as a tobacco membrane for cigarettes. However, we found reports of cigarette use cases having implications for the severity of spontaneous pneumothorax disease. A 57-year-old man came to the emergency room suffering from shortness of breath, right-side chest discomfort, yellowish-green sputum cough, abdominal pain, nausea, weakness, decreased appetite, and inability to sleep. For two years, this man consumed ten Nipah membrane cigarettes he made independently daily, resulting in lung disease. The lungs were found to be asymmetrical with the weakened fremitus of the right lung stem; percussion revealed hyper resonance in the right lung and resonance in the left lung; auscultation revealed the presence of a decrease in vesicular breathing sounds in the right lung, and other breathing sounds crackling in both lungs. The patient's severe partially compensatory respiratory acidosis indicated levels of pH, pO2, pCO2, HCO3, total CO2, and BE. Sinus tachycardia, normoaxis and suitable atrial hypertrophy were found. The luscen region is visible, and the white line of the pleura on the right hemithorax shows the pneumothorax of the right lung. This case is relatively rare, and excess Nipah leaf membrane cigarettes increase the severity of spontaneous pneumothorax disease that causes COPD.
Gambaran Pengetahuan Dan Sikap Ibu Dalam Mengobati Diare Menggunakan Tanaman Tradisional di Desa Milangasri Magetan Samuel Budi Harsono; Irfan Zamzani; Liana Djeli Maesaroh
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2844

Abstract

In Indonesia, traditional medicine is still widely used by the community. Riskesdas data from 2010 to 2018, shows the use of traditional medicines has increased by 44.3%. The use of these traditional medicines to treat various diseases, one of which is diarrhea. Knowledge about the use of traditional medicinal plants to prevent and treat diarrhea has been passed down from generation to generation. The purpose of this study is to provide an overview of the knowledge and attitudes of mothers in treating diarrhea using traditional plants. This research is a non-experimental quantitative research with descriptive data presentation. Sampling was done by non random sampling technique using purposive sampling method. The research instrument used questionnaires and leaflets as educational media. Data analysis used the Kolmogorov-Smirnov test and the Wilcoxon test. The research sample was mothers aged 21-55 years who were in Milangasri Village, Magetan Regency. The results of the study obtained the number of samples of 95 respondents. The level of knowledge in the pre-test in the good category is 37.89% and the post-test in the good category is 91.58%, while the attitude level for the pre-test in the good category is 51.58% and the post-test in the good category is 89.47%. Kolmogorov test obtained results 0.000 < 0.05 which means the data is not normally distributed and Wilcoxon test results obtained 0.00 < 0.05 which indicates the influence of education on the level of knowledge and attitudes of respondents.
Pengaruh Suhu Dekoksi Terhadap Kadar Kurkumin Dan Aktivitas Antioksidan Pada Rimpang Temulawak (Curcuma Zanthorrhiza) Baiq Desy Ratnasari; Diah Miftahul Aini
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2850

Abstract

One of the medicinal plants that are widely used and available is Curcuma xanthorrhiza. In a daily consumption, C. xanthorrhiza is processed into herbal drinks through a decoction process. However, many biological activities of a plant may be sensitive to the temperature due. Thus, this study is analyzing the effect of temperature on one of the major compounds of C. xanthorrhiza, namely curcumin, along with its antioxidant activity. This research was conducted to obtain the optimum temperature for C. xanthorrhiza processing in order to standardize it as phytopharmaca product. The results showed that a temperature of 100oC was the optimal temperature for the decoction with an extraction rate of 8 ppm and an antioxidant activity of 165 ppm. The curcumin content seems not too sensitive to temperature when seen from the levels obtained at 70oC, 90oC and 100oC which are both 8 ppm. On the other hand, the antioxidant activity of C. xanthorrhiza at temperatures below 100oC has no significant activity which indicates the effect of temperature on its antioxidant activity. The curcumin standard itself has an IC50 of 120 ppm while the IC50 of vitamin C is 24.3 ppm. As it seen from the insignificant antioxidant activity of the decoction extract below 100oC, it is possible that there are other compounds besides curcumin which are extracted only at 100oC which has the agonist effect on the antioxidant activity
Formulasi dan Uji Sifat Fisik Sediaan Krim dari Ekstrak Watermelon Rind ((Citrullus lanatus).(Thunb)). Anisabeth Yan; Irma Novrianti; Faizal Mustamin
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2852

Abstract

Indonesia has a tropical climate which makes the body produce excess oil. This triggers the occurrence of acne, because it can clog skin pores and cause the formation of bacterial colonies. Watermelon is a fruit that has many health benefits. Generally, people consume the contents and throw away the white flesh and skin (watermelon rind), even though this part has good benefits for the skin because it contains several biochemical compounds that act as antibacterial. One of the preparations used for skin problems is cream. This study aims to produce a formula for the preparation of watermelon rind extract cream that complies with pharmaceutical requirements and is stable in storage. Watermelon rind cream preparation is made with a concentration of watermelon rind extract, namely FI 7.5%; FII 12.5%, and FIII 20%. Finished preparations were tested for physical stability which included organoleptic tests, homogeneity, pH, irritation tests, cream type tests, spreadability and stability tests. The watermelon rind extract cream obtained is green in color, has a distinctive smell of extract and rose oil, is homogeneous, and is of the M/A type. The pH of the watermelon rind extract cream is in a range that is still acceptable to the skin and has good spreadability and does not cause irritation to the skin. During the storage period, the watermelon rind extract cream did not experience physical changes and homogeneity, and did not experience a significant decrease in pH and spreadability with a p-value > 0.05. This shows that the preparation of watermelon rind extract cream meets pharmaceutical requirements and is stable during storage.
Penetapan Kadar Fenol Total Dan Aktivitas Antioksidan Dari Ekstrak Etanol Kulit Kentang (Solanum Tuberosum L.) Vinda Maharani Patricia; Tasya Luthfiyyah; Livia Syafnir
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2886

Abstract

Indonesia is one of the countries with a diversity of plants, one of which is the potato plant (Solanum tuberosum L.). Some compounds found in potato peels have pharmacological activities, one of which is antioxidants. This study aimed to determine the total phenol content and the antioxidant activity produced by potato peel ethanol extract. The methods for total phenolic content used the Folin-Ciocalteu method and the DPPH(2,2-diphenyl-1-picrylhydrazyl) method for antioxidant activity. The result obtained from this study was that the total phenol content in ethaol extract of potato peel was 152.9 mg GAE / g extract and antioxidant activity showed with IC50 value was 30,339 ppm, which means that potato peel ethanol extract has a very strong antioxidant activity.
Formulasi dan Evaluasi Gel Pelembap Ekstrak Mesokarp Semangka [Citrullus lanatus (Thunb.) Matsum. & Nakai] sebagai Antioksidan Sari Defi Okzelia; Waffiyyatul Mardiyyah
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2892

Abstract

Dry skin is the most common skin problem, so moisturizers are used to prevent it. White skin (mesocarp) of watermelon [Citrullus lanatus (Thunb.) Matsum. & Nakai] (MW) has the potential to be formulated into a moisturizing gel preparation since it contains vitamins and citrulline which also possess antioxidant activity. This study aimed to formulate a moisturizing gel preparation from MW extract as an antioxidant. MW was extracted by maceration using 70% ethanol and formulated into moisturizing gel preparation at concentrations of 5% (F1), 10% (F2), and 15% (F3). Gel preparations were evaluated physically, and determined their moisture content and antioxidant activity. MW extract was a brown color with 25.02% yield. The evaluation results showed that all formulations met the standard parameters of good gel preparations including organoleptic, homogeneity, spread-ability, adhesion, pH, and viscosity, and did not irritate the skin. The skin moisture after application of F1, F2, and F3 respectively were 29.49%; 36.63%; and 43.48%. IC50 values for F1, F2, and F3 respectively were 156.42; 149.24, and 138.05 µg/mL. The moisturizing gel preparation from MW extract met all the standard parameters of good gel preparation, could increase the percentage of skin moisture, and had moderate antioxidant activity.
The Physical Quality Test of Anti-Acne Gel Preparations of Shallot Skin Extract (Allium cepa L) and Antibacterial Activity Test Against Propionibacterium acne Bacteria Nafisah Isnawati; Dina Trianggaluh Fauziah
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2916

Abstract

Shallot skin is a simplicia that contains secondary metabolites such as polyphenols, saponins, terpenoids, alkaloids, and flavonoids that are efficacious as antibacterials. The purpose of this research was to formulate and evaluate the physical quality of shallot skin extract gel preparation (Allium cepa L.) and test the anti-bacterial activity against bacteria. Propionibacterium acne is one of the causes of acne. The research method is experimental research by making a gel preparation formula of shallot skin extract then physical testing and testing antibacterial activity against Propionibacterium acnes bacteria. The results showed that the shallot skin extract gel preparation had good homogeneity, gel texture, and a distinctive aroma of shallots and a slightly brown-yellow color. The pH and spreadability tests fulfill the gel preparation requirements. The adhesion and viscosity tests of the three formulas did not reach the requirements of gel preparations. The inhibitory power of the gel preparation is in a strong category. In conclusion, shallot skin extract gel preparation has inhibition against Propionibacterium acnes bacteria.
Hubungan Status gizi, Anemia, Faktor Stress dan Kualitas Tidur dengan Siklus Menstruasi Remaja di Pesantren Kartika Pibriyanti; Mardhatillah Mardhatillah; Lulu’ Luthfiya; Amilia Yuni Damayanti; Indahtul Mufida; Cut Kemala Handayani; Reni Indrayanti Fernandes
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.2918

Abstract

Infertility is a global health problem that affects millions of reproductive age worldwide. Infertility can be caused by menstrual cycle problems. Menstrual cycles altered often occur in adolescents with a prevalence of >65%. Changes in the menstrual cycle are influenced by several factors to avoid complications adolescents expected to monitor their menstrual cycle. This research was an observational quantitative research with cross-sectional method. The result of this research were most respondents aged 12 years as many as 62 respondents (64.6%). Most respondents had normal nutritional status of 76 respondents (79.2%) with the number of non-anemic respondents as many as 73 respondents (76%). Most of the respondents experienced stress as many as 83 respondents (86.5%) and poor sleep quality as many as 70 respondents (72.9%). Meanwhile, the most common menstrual cycle disorder was Amenorrhea with 70 respondents (72.9%). In this research it can be concluded that there was no relationship between nutritional status (p=1.000), stress factors (p=0.744), sleep quality (p=1.000) and menstrual cycle in adolescents at Boarding School but there was a relationshop between anemia and menstrual cycle in adolescents at Boarding School (p=0.022).
Uji Efek Nefroprotektif Ekstrak Kulit Buah Mangga Arumanis (Mangifera indica L) Secara In Vivo Diinduksi Gentamisin Ifmaily Ifmaily; Irwandi Irwandi; Essi Fadila Warni
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3075

Abstract

Mango rind is one of the organic wastes after we eat the fruit. In previous studies, mango rind extract has been shown to have antihypertensive, antidiabetic, and antioxidant effects from its secondary metabolite flavonoids. The purpose of this study was to determine the effect of mango rind extract (EKBM) as a nephroprotector in male rats, and to determine the effect of varying doses of EKBM as a nephroprotector in male rats using creatinin level, ureum level, and weight ratio of rats’kidney. This study was purely experimental, using 25 white male rats with 5 groups of rats consisting of 5 rats per groups. The group was a negative control group, positive control, doses of 100 mg/kgbw, 150 mg/kgbw, 200 mg/kgbw, except for the negative control, all of which were induced with gentamicin for 5 days. On the 9th day, blood was taken through the orbital vein, then centrifuged, the serum was taken to check the creatinine level, then the rats were killed and weighed by the weight ratio of the rat kidneys. The results of this study were negative control, positive control, doses of 100 mg/kgbw, 150 mg/kgbw, and 200 mg/kgbw for creatinine levels in rats 0.74; 2.7; 0.76; 1,37; 1.4 (mg/dl), ureum levels; 28,7; 125,8; 28,9; 35,8; 43,5 ( mg/dl ) and for animal kidney weight 1,97 ; 2,74 ; 2,13 ; 2,15 ; dan 2,19 (%). The conclusion is that mango rind extract can provide a nephroprotector effect and the mango rind extract can provide a nephroprotector effect with an effective dose of 100 mg/kgbb with a p value = 0.047
Perbandingan Pertumbuhan Bayi dengan Pemberian ASI Ekslusif dan Non Ekslusif Nurbaiti Br. Singarimbun; Suharni Pintamas Sinaga; Selli M. Pasaribu
Journal of Pharmaceutical and Health Research Vol 4 No 1 (2023): February 2023
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v4i1.3107

Abstract

Nutrition is a nutritional intake that plays an important role during the period of growth and development in infants. The nutrition that babies aged 0-6 months need comes from exclusive breastfeeding. About 13% of infant mortality can be reduced through exclusive breastfeeding. The study aims to determine the comparison of infant growth with exclusive and non-exclusive breastfeeding. The research method used was a descriptive design with a population of 50 infants aged 6 months at the Bawomataluo Health Center. The results of the analysis showed that the average growth of babies who were given exclusive breastfeeding based on body weight was 6.11, body length was 65.68 and head circumference was 42.72. While the average growth of babies with non-exclusive breastfeeding based on body weight was 4.56, body length was 56.56 and head circumference was 37.96. Differences in infant growth based on body weight, body length and head circumference as well as infant development between exclusively and non-exclusively breastfed infants (p = 0.000 <0.05). The conclusion shows that the growth of babies at the Bawomataluo health center with exclusive breastfeeding is better than non-exclusive.

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